The left-hander will be making his first Major League start in his home country of Canada. Diamond's hometown of Guelph, Ontario, is about 60 miles away from Toronto.
Initially, Diamond's chances to start again were in doubt. He has already thrown more than 200 innings this season between his stints with the Twins and Triple-A Rochester. But Diamond has been adamant about making the start.
"We've talked about how this might be enough, but he really wants to pitch," manager Ron Gardenhire said. "It's a big start for him. I think, mentally, he really wants this desperately. He thinks it's really important to make this start in Canada, where he's from."
Diamond, who owns a 12-8 record with a 3.54 ERA, will have many family members in attendance at Rogers Centre on Wednesday.
"It's going to be pretty exciting," Diamond said. "I've never been able to pitch there. I'm definitely going to have some friends and family there, so it's going to be kind of a homecoming. I'm pretty excited about it."
Meanwhile, the Twins' batters might not be as excited to face Toronto starter Brandon Morrow.
After struggling with inconsistency since returning from an oblique strain that kept him out for two months, Morrow dominated the Yankees in his last start on Sept. 27. The right-hander threw seven shutout innings while allowing four hits and three walks.
"It takes a little while to get back in the groove," he said. "But I have felt good since I've come back. The inconsistent starts can be attributed to whatever, who knows? Tonight I got back a little bit better into the kind of rhythm I was earlier [in the season] with all four pitches."
Twins: Doumit's season likely over
• Like Josh Willingham, the Twins will likely end the season without Ryan Doumit available. Doumit was held out of Minnesota's lineup for Tuesday's game due to an injured thumb, and he is also expected to miss Wednesday's season finale. Gardenhire said Doumit may be able to pinch-hit in an emergency situation.
Doumit is hitting .275 with a career-high 18 home runs and 75 RBIs through 134 games.
"He thinks he could probably hit right-handed in a pinch, but he can't catch," Gardenhire said. "His thumb is better than it was yesterday. It was really ugly."
• Ben Revere's 40th stolen base of the season on Monday made him the first Twin to reach the 40-steal plateau since Chuck Knoblauch swiped 62 bags in 1997. Revere is one steal short of tying Rod Carew for sixth on Minnesota's all-time single-season list.
Blue Jays: Encarnacion may not play again this year
• Edwin Encarnacion may not play in another game this season after missing his second straight contest on Tuesday. The infielder is dealing with tightness in his trapezius muscle and hasn't played since being pulled from Sunday's game against New York in the seventh inning.
"We will reevaluate him tomorrow," manager John Farrell said. "I can't give you a percentage of [whether] he will be in the lineup tomorrow or not."
• Besides acquiring starting pitching, Farrell would like for Toronto to acquire players with high on-base percentages. The Blue Jays' only current everyday players with on-base percentages above .330 are Encarnacion and Jose Bautista.
"I think any time you can lengthen out a lineup and upgrade, that's a plus," Farrell said.
• Before Monday's series opener, the Twins and Blue Jays hadn't played each other in Toronto in 547 days. That was tied for the longest gap between games for a road-home matchup in MLB history (intraleague matchups only), excluding strike seasons, since the Astros and Rockies went 547 days from 2003-2004.
• If Joe Mauer plays in Wednesday's game, it will be his 147th of the season, surpassing his 2008 career-best total of 146 games.